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Pyrimidine is a 6-membered ring consisting of four carbon atoms and two nitrogen centers at the 1- and 3- ring positions.

These are polycyclic aromatic compounds containing a benzene ring linked to a pyrimidine ring through a CC or CN bond.

Miscellaneous Anxiolytics Sedatives and HypnoticsĬhemical Taxonomy Provided by Classyfire Description This compound belongs to the class of organic compounds known as phenylpyrimidines.

gamma-Aminobutyric Acid A Receptor Agonist.

Previous Next International/Other Brands Zalaplon Brand Name Prescription Products Name The risk or severity of adverse effects can be increased when Zaleplon is combined with Acetophenazine. The risk or severity of adverse effects can be increased when Acetazolamide is combined with Zaleplon. The metabolism of Zaleplon can be decreased when combined with Acalabrutinib.Īceclofenac may decrease the excretion rate of Zaleplon which could result in a higher serum level.Īcemetacin may decrease the excretion rate of Zaleplon which could result in a higher serum level.Īcetaminophen may decrease the excretion rate of Zaleplon which could result in a higher serum level. The metabolism of Zaleplon can be increased when combined with Abatacept. The serum concentration of Zaleplon can be increased when it is combined with Abametapir. Zaleplon may decrease the excretion rate of Abacavir which could result in a higher serum level. The risk or severity of adverse effects can be increased when Zaleplon is combined with 1,2-Benzodiazepine. TargetĪ Gamma-aminobutyric acid receptor subunit alpha-1

Zaleplon also binds selectively to the brain omega-1 receptor located on the alpha subunit of the GABA-A/chloride ion channel receptor complex and potentiates t-butyl-bicyclophosphorothionate (TBPS) binding. Zaleplon exerts its action through subunit modulation of the GABA BZ receptor chloride channel macromolecular complex. Zaleplon also binds selectively to the CNS GABA A-receptor chloride ionophore complex at benzodiazepine(BZ) omega-1 (BZ1, ο1) receptors.

Subunit modulation of the GABA BZ receptor chloride channel macromolecular complex is hypothesized to be responsible for some of the pharmacological properties of benzodiazepines, which include sedative, anxiolytic, muscle relaxant, and anticonvulsive effects in animal models. While Zaleplon is a hypnotic agent with a chemical structure unrelated to benzodiazepines, barbiturates, or other drugs with known hypnotic properties, it interacts with the gamma-aminobutyric acid-benzodiazepine (GABA BZ) receptor complex. Zaleplon is a nonbenzodiazepine hypnotic from the pyrazolopyrimidine class and is indicated for the short-term treatment of insomnia.